Amphetamines are controlled substances in the USA with the C-II designation. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine. Stimulants have caused stroke, heart attack, and sudden death in people with high blood pressure, heart disease, or a heart defect. Amphetamine is a central nervous system stimulant that affects chemicals in the brain and nerves that contribute to hyperactivity and impulse control.

Treatment / Management

They’re often used and misused in search of a “high,” or to boost energy, to improve performance at work or school, or to lose weight or control appetite. Amphetamines belong to a class of CNS stimulants called phenethylamines. Amphetamines contain a methyl group to the alpha position on its carbon chain resulting in lipophilicity, increasing its volume of distribution, and CNS stimulation. Amphetamines block monoamine reuptake transport systems resulting in high synaptic concentrations.

Preventing drug misuse in children and teenagers

  • Unlike opioid addiction, for which medication-assisted treatment is the standard of care, no medication has been approved by the Food and Drug Administration for use with meth.
  • Amphetamines are illegal when they are used without a prescription to get high or improve performance.
  • By Corinne O’Keefe OsbornCorinne Osborn is an award-winning health and wellness journalist with a background in substance abuse, sexual health, and psychology.
  • Amphetamines are also indirect neurotransmitters leading to increased cytosolic levels of monoamines.

Amphetamine is a medication used in the management and treatment of ADHD and narcolepsy. This activity reviews the indications, action, and contraindications for amphetamine as an agent in treating ADHD and narcolepsy. Follow all directions on your prescription label and read all medication guides or instruction sheets. Taking amphetamine during pregnancy can cause premature birth, low birth weight, or withdrawal symptoms in the newborn baby.

A Speedy History of America’s Addiction to Amphetamine – Smithsonian Magazine

A Speedy History of America’s Addiction to Amphetamine.

Posted: Fri, 27 Oct 2017 07:00:00 GMT [source]

Treatment of Stimulant Use Disorders

This review was conducted using the Cochrane Collboration standards for preparing systematic reviews. Increased HIV and hepatitis B and C transmission are possible related consequences of increased methamphetamine abuse, not only in individuals who inject the drug but also in non-injecting methamphetamine abusers. Among injection Amphetamine Addiction drug users, infection with HIV and other infectious diseases is spread primarily through the use of contaminated syringes, needles, or other paraphernalia by more than one person. The intoxicating effects of methamphetamine can also alter judgment and inhibition, which may lead people to engage in unsafe behaviors.

Amphetamine dependence

The most consistent positive findings have been demonstrated with stimulant agonist treatment (dexamphetamine and methylphenidate), naltrexone and topiramate. Less consistent benefits have been shown with bupropion, the glutamatergic agent, riluzole, and antidepressant mirtazapine, whilst in general, antidepressant medications (e.g. SSRIs, TCAs) have not been effective in reducing AMPH/MA use. One study (2%) examined amineptine [300 mg oral (po) daily (OD)], an atypical tricyclic antidepressant, in inpatient participants for AMPH withdrawal over 14 days [43]. Participants randomised to amineptine were significantly less depressed at Day 7 and had improved clinical global impression scores at Day 14 in the completer analysis (i.e. only those completing study protocol) compared with placebo. In terms of feasibility, amineptine has never been approved by the US Federal Drug Administration (FDA) and has been suspended in other jurisdictions due to hepatotoxic effects and abuse liability.

  • Examples include methylenedioxymethamphetamine, also called MDMA, ecstasy or molly, and gamma-hydroxybutyric acid, known as GHB.
  • Among injection drug users, infection with HIV and other infectious diseases is spread primarily through the use of contaminated syringes, needles, or other paraphernalia by more than one person.
  • It is used to treat some medical conditions, but it is also highly addictive, with a history of abuse.
  • Anyone who has been using amphetamines for an extended period of time can experience withdrawal symptoms.

What Is Amphetamine Addiction, Tolerance, and Dependence?

  • Despite manufacturer claims, these are chemical compounds rather than “natural” or harmless products.
  • There was no statistically significant main or interaction effect of either sertraline or CM for measures of MA use.
  • They treat attention deficit hyperactivity disorder and narcolepsy, a sleep disorder.
  • Another study examined sustained-release oral dexamphetamine (30 mg po BD) for 60 MA-dependent participants [35].
  • The 2015 National Survey on Drug Use and Health (NSDUH) reports that about 4.8 million people in the US abused prescription amphetamine medications that year, equivalent to about 1.8 percent of the population that is 12 and older.
  • Furthermore, using BCBT is likely to increase the outcome of pharmacological treatments for amphetamines abuse in clinical practice.
  • During periods of non-use, the user may recall the feeling of euphoria produced by the drug and desire to take it again.

Adverse effects

Amphetamine dependence